Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
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چکیده
منابع مشابه
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
INTRODUCTION Sepsis is responsible for important alterations in the pharmacokinetics of antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in septic patients, may further contribute to pharmacokinetic changes. Current recommendations for antibiotic doses during CRRT combine data obtained from heterogeneous patient populations in which different CRRT devices and tec...
متن کاملBeta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy
Although early and appropriate antibiotic therapy remains the most important intervention for successful treatment of septic shock, data guiding optimization of beta-lactam prescription in critically ill patients prescribed with continuous renal replacement therapy (CRRT) are still limited. Being small hydrophilic molecules, beta-lactams are likely to be cleared by CRRT to a significant extent....
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INTRODUCTION The use of standard doses of β-lactam antibiotics during continuous renal replacement therapy (CRRT) may result in inadequate serum concentrations. The aim of this study was to evaluate the adequacy of unadjusted drug regimens (i.e., similar to those used in patients with normal renal function) in patients treated with CRRT and the influence of CRRT intensity on drug clearance. M...
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Methods We retrospectively identified all patients admitted to our department of Intensive Care during a two-year period (2012-2013) who required CRRT at any time during ICU stay, who died and had post-mortem (PM) examination. Predefined exclusion criteria were: history of end-stage kidney disease requiring dialysis before admission, CRRT required for any reason other than kidney failure and de...
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Electrolyte and mineral disturbances remain a major concern in patients undergoing continuous renal replacement therapy (CRRT); however, it is not clear whether those imbalances are associated with adverse outcomes in patients with septic acute kidney injury (AKI) undergoing CRRT. We conducted a post-hoc analysis of data from a prospective randomized controlled trial. A total of 210 patients wi...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2011
ISSN: 1364-8535
DOI: 10.1186/cc10257